Data underlying the publication: Organochlorides Mediate Oxidation Reactions Induced by Low Dose Ionizing RadiationOrganochlorides Mediate Oxidation Reactions Induced by Low Dose Ionizing Radiation

DOI:10.4121/882b82f6-0a21-445a-a0ae-65324c73cb05.v1
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DOI: 10.4121/882b82f6-0a21-445a-a0ae-65324c73cb05

Datacite citation style

Liu, Juncheng; Brevé, Tobias G.; Xu, Bing; Hagedoorn, Peter-Leon; Denkova, Antonia et. al. (2024): Data underlying the publication: Organochlorides Mediate Oxidation Reactions Induced by Low Dose Ionizing RadiationOrganochlorides Mediate Oxidation Reactions Induced by Low Dose Ionizing Radiation. Version 1. 4TU.ResearchData. dataset. https://doi.org/10.4121/882b82f6-0a21-445a-a0ae-65324c73cb05.v1
Other citation styles (APA, Harvard, MLA, Vancouver, Chicago, IEEE) available at Datacite

Dataset

The controlled release of drugs using local ionizing radiation presents a promising approach for targeted cancer treatment, particularly when applied in concurrent radio-chemotherapy. In these approaches, radiation-generated reactive species often play an important role. However, the reactive species that can be used to trigger release have low yield and lack selectivity. Here, we demonstrate the generation of highly oxidative species when aqueous solutions containing low concentrations of organochlorides (such as chloroform) are irradiated with ionizing radiation at therapeutically relevant doses. These reactive species were identified as peroxyl radicals, which formed in a reaction cascade between organochlorides and aqueous electrons. We employed stilbene-based probes to investigate the oxidation process, showing double bond oxidation and cleavage. To translate this reactivity into a radiation-sensitive material, we have synthesized a micelle forming amphiphilic block copolymer that has stilbene as the linker between two blocks. Upon exposure to ionizing radiation, the oxidation of stilbene led to the cleavage of the polymer, which induces the dissociation of the block-copolymer micelles and the release of loaded drugs.

History

  • 2024-10-17 first online, published, posted

Publisher

4TU.ResearchData

Format

UV spectrum raw data/.CSV; Origin plot data/.opju; graphs/.tif; NMR data/.mnova; TEM images/.tif; EPR raw data/.DSC

Funding

  • China Scholarship Council (CSC)

Organizations

TU Delft, Faculty of Applied Sciences, Department of Radiation Science & Technology

DATA

Files (16)