TY - DATA T1 - Data underlying the publication: Organochlorides Mediate Oxidation Reactions Induced by Low Dose Ionizing RadiationOrganochlorides Mediate Oxidation Reactions Induced by Low Dose Ionizing Radiation PY - 2024/10/17 AU - Juncheng Liu AU - Tobias G. Brevé AU - Bing Xu AU - Peter-Leon Hagedoorn AU - Antonia Denkova AU - Rienk Eelkema UR - DO - 10.4121/882b82f6-0a21-445a-a0ae-65324c73cb05.v1 KW - drug delivery KW - micelles KW - radiation chemistry KW - reactive oxygen species KW - ionizing radiation KW - reaction mechanisms N2 -

The controlled release of drugs using local ionizing radiation presents a promising approach for targeted cancer treatment, particularly when applied in concurrent radio-chemotherapy. In these approaches, radiation-generated reactive species often play an important role. However, the reactive species that can be used to trigger release have low yield and lack selectivity. Here, we demonstrate the generation of highly oxidative species when aqueous solutions containing low concentrations of organochlorides (such as chloroform) are irradiated with ionizing radiation at therapeutically relevant doses. These reactive species were identified as peroxyl radicals, which formed in a reaction cascade between organochlorides and aqueous electrons. We employed stilbene-based probes to investigate the oxidation process, showing double bond oxidation and cleavage. To translate this reactivity into a radiation-sensitive material, we have synthesized a micelle forming amphiphilic block copolymer that has stilbene as the linker between two blocks. Upon exposure to ionizing radiation, the oxidation of stilbene led to the cleavage of the polymer, which induces the dissociation of the block-copolymer micelles and the release of loaded drugs.

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