TY - DATA
T1 - Data underlying the publication "Equibiaxial and uniaxial cyclic strain similarly affect Notch signaling and vascular smooth muscle cell phenotype in 2D"
PY - 2025/05/20
AU - Cansu Karakaya
AU - Mark C. van Turnhout
AU - Eva A.N. van den Hurk
AU - Carlijn V.C. Bouten
AU - Cecilia M. Sahlgren
AU - Sandra Loerakker
UR - 
DO - 10.4121/6964ba10-be3a-4673-ba90-fb554ec751dd.v1
KW - Notch signaling
KW - vascular smooth muscle cells
KW - phenotype
KW - strain anisotropy
N2 - <p>This study explored how strain anisotropy affects mechanosensitive Notch signaling and the resulting phenotype of vascular smooth muscle cells (VSMCs). We applied cyclic strains within the physiological range to compare the effects of equibiaxial and uniaxial loading on Notch activity and phenotypic changes in both synthetic and contractile VSMCs. By assessing three deformation parameters, we aimed to identify the main strain feature influencing these responses. Our findings indicate that VSMCs react similarly to both strain types, suggesting that strain anisotropy may not have a significant impact on Notch signaling and phenotype modulation.</p><p><br></p><p>This dataset contains the videos and data for strain analysis, immunofluorescence staining images, and real-time polymerase chain reaction data.</p>
ER -