TY - DATA
T1 - Data underlying the publication: Unjamming transitions in cancer cell spheroids are linked to EMT-dependent cell-matrix interactions
PY - 2024/04/10
AU - Anouk van der Net
AU - Zaid  Rahman
AU - Ankur  Deep Bordoloi
AU - Iain Muntz
AU - Peter ten Dijke 
AU - Pouyan Boukany
AU - G.H. (Gijsje) Koenderink
UR - 
DO - 10.4121/3af75b5a-db30-419c-97ab-a5f632812a6c.v1
KW - hydrogel
KW - melanoma cancer
KW - lung cancer
KW - cancer invasion
KW - unjamming
KW - TGF-β
KW - Matrix metalloproteases
N2 - <p>Datasets for the publication "Unjamming transitions in cancer cell spheroids are linked to EMT-dependent cell-matrix interactions", to be submitted.</p><p>Datasets include the raw tif files of 3D spheroid invasion assays of A549 and MV3 spheroids embedded in collagen (2.4 and 8 mg/mL) and gelMA (30 and 50 mg/mL). This include time-series bright-field imaging for 24 hrs (MV3) and 72 hrs (A549) at one hour interval. The spheroids were treated with exogenous TGF-β and broad spectrum MMP-inhibitor and imaged under same conditions.</p><p>Datasets include MATLAB/.m codes to analyze the spheroid images for effective spheroid radius, number of disseminated cells, rate of invasion and protrusion length. Additionally, MATLAB codes/.m to plot figures are also included within each respective condition. Raw data for supplementary data is also provided as images, excel files and MATLAB scripts.</p>
ER -