%0 Generic
%A Nagle, Irène
%A Tavasso, Margherita
%A Deep Bordoloi, Ankur 
%A Muntz, Iain
%A Koenderink, G.H. (Gijsje)
%A Boukany, Pouyan
%D 2025
%T Data underlying the manuscript: Invasive cancer cells soften collagen networks and disrupt stress stiffening via volume exclusion, contractility and adhesion
%U 
%R 10.4121/5dd62a23-7f71-4674-b232-7c8316ce5492.v1
%K Cell-matrix interactions
%K Shear rheology
%K Actin cytoskeleton
%K Tissue mechanics
%K Active matter
%K Rheo-confocal microscopy
%X <p>The research investigates how local cell–ECM interactions regulate the global mechanics of collagen networks in a biomimetic tissue model composed of type I fibrillar collagen with embedded cancer cells (volume fractions: 0.4%–20%). Experiments compare the behavior of human dermal fibroblasts and MDA-MB-231 breast cancer cells, which are known to actively remodel collagen networks. Collagen polymerization and network mechanics were characterized using bulk shear rheology. A custom-built rheo-confocal microscope was used to visualize real-time local remodeling of collagen during polymerization. All raw data, processed results, and MATLAB/python scripts for data analysis and figure generation are included.</p>
%I 4TU.ResearchData