cff-version: 1.2.0
abstract: "<p>The research investigates how local cell–ECM interactions regulate the global mechanics of collagen networks in a biomimetic tissue model composed of type I fibrillar collagen with embedded cancer cells (volume fractions: 0.4%–20%). Experiments compare the behavior of human dermal fibroblasts and MDA-MB-231 breast cancer cells, which are known to actively remodel collagen networks. Collagen polymerization and network mechanics were characterized using bulk shear rheology. A custom-built rheo-confocal microscope was used to visualize real-time local remodeling of collagen during polymerization. All raw data, processed results, and MATLAB/python scripts for data analysis and figure generation are included.</p>"
authors:
  - family-names: Nagle
    given-names: Irène
    orcid: "https://orcid.org/0009-0008-5201-2472"
  - family-names: Tavasso
    given-names: Margherita
    orcid: "https://orcid.org/0009-0003-2671-0764"
  - family-names: Deep Bordoloi
    given-names: Ankur 
  - family-names: Muntz
    given-names: Iain
    orcid: "https://orcid.org/0000-0002-8434-8316"
  - family-names: Koenderink
    given-names: G.H. (Gijsje)
    orcid: "https://orcid.org/0000-0002-7823-8807"
  - family-names: Boukany
    given-names: Pouyan
    orcid: "https://orcid.org/0000-0002-2262-5795"
title: "Data underlying the manuscript: Invasive cancer cells soften collagen networks and disrupt stress stiffening via volume exclusion, contractility and adhesion"
keywords:
version: 1
identifiers:
  - type: doi
    value: 10.4121/5dd62a23-7f71-4674-b232-7c8316ce5492.v1
license: CC BY 4.0
date-released: 2025-04-15