cff-version: 1.2.0
abstract: "<p>This dataset contains the data for the manuscript "Blood-perfused Vessels-on-Chips stimulated with patient plasma recapitulate endothelial activation and microthrombosis in COVID-19", to be published. Within the data are multiple sets:</p><ul><li>clinical data from included patients and controls; including admission time in hospital, diagnostic measurements when first included, outcome of admission, and VTE status during admission</li><li>Cytokine ELISAs of IL-6, IL-10, TNF-a, IFN-y, CXCL-10, measured in the derived plasma of hospitalized patients</li><li>Raw reads of RNA sequencing of hiPSC derived endothelial cells, after cells were stimulated with diluted patient plasma overnight to induce changes in their phenotype</li><li>Raw pathogen counts based on said RNA sequencing data, where non-human RNA reads are quantified per sample</li><li>Platelet coverage data after hiPSC-ECs were stimulated with derived plasma on-chip, where the stimulated chips were perfused with human whole blood to recapitulate the thrombotic adverse events that occur in some COVID patients.</li></ul>"
authors:
  - family-names: Weener
    given-names: Huub
    orcid: "https://orcid.org/0000-0002-1568-5394"
  - family-names: van Haaps
    given-names: Thijs
    orcid: "https://orcid.org/0000-0002-8358-2426"
  - family-names: van Helden
    given-names: Ruben
    orcid: "https://orcid.org/0000-0001-8288-8717"
  - family-names: Albers
    given-names: Hugo
    orcid: "https://orcid.org/0000-0003-3807-5035"
  - family-names: Haverkate
    given-names: Rozemarijn
  - family-names: Middelkamp
    given-names: Heleen
    orcid: "https://orcid.org/0000-0003-0267-8811"
  - family-names: Ridderikhof
    given-names: Milan
    orcid: "https://orcid.org/0000-0002-1561-7252"
  - family-names: van Mens
    given-names: Thijs
    orcid: "https://orcid.org/0000-0002-6520-1597"
  - family-names: van den Berg
    given-names: Albert
    orcid: "https://orcid.org/0000-0001-9019-933X"
  - family-names: Mummery
    given-names: Christine
    orcid: "https://orcid.org/0000-0002-4549-6535"
title: "Data of manuscript Blood-perfused Vessels-on-Chips stimulated with patient plasma recapitulate endothelial activation and microthrombosis in COVID-19"
keywords:
version: 1
identifiers:
  - type: doi
    value: 10.4121/5bb846d8-ed30-4e2e-bfe3-4fb607cbe8ed.v1
license: CC BY-NC 4.0
date-released: 2024-09-17