BioBrAIn: 700L bioreactor - CFD-derived data

DOI:10.4121/f8d32b7c-0477-4b87-a038-39e55c8a7379.v1
The DOI displayed above is for this specific version of this dataset, which is currently the latest. Newer versions may be published in the future. For a link that will always point to the latest version, please use
DOI: 10.4121/f8d32b7c-0477-4b87-a038-39e55c8a7379

Datacite citation style

Maldonado de León, Héctor; Haringa, Cees (2025): BioBrAIn: 700L bioreactor - CFD-derived data. Version 1. 4TU.ResearchData. dataset. https://doi.org/10.4121/f8d32b7c-0477-4b87-a038-39e55c8a7379.v1
Other citation styles (APA, Harvard, MLA, Vancouver, Chicago, IEEE) available at Datacite

Dataset

This case is based on the studies from Spann et al. and Tajsoleiman et al. on the formation of pH gradients in a 700 L batch fermentation of Streptococcus thermophilus. These studies employed a single-phase CFD simulation to predict the evolution of pH gradients experimentally observed, and then assessed their effect on growth when coupled to a biokinetic model. Later, Nadal-Rey et al. utilized this reactor geometry to propose a workflow for developing a dynamic compartment model based on a library of staggered simulations, aiming to obtain a close-to-real-time representation of the hydrodynamics and respective gradients of substrate and oxygen.


Here, we constrained ourselves to solely solve for the flow fields based on this bioreactor geometry for different combinations of operating conditions. The combinations of operating conditions were sampled via a Latin-Hypercube-Sampling (LHS) approach, which stratifies each factor and selects one value per stratum to achieve near-uniform coverage with far fewer samples than simple random sampling. Hence, two distinct sets are shared: 1) With fixed impeller configuration, and 2) variable impeller configuration.


Further details about the meshing workflow, models implemented, and their parameterization can be found in the README.md file.


This dataset is part of the BioBrAIn collection - A CFD database of bioreactors.

History

  • 2025-11-07 first online, published, posted

Publisher

4TU.ResearchData

Format

CFD-derived data/.csv or.encas, Fluent Case-Data files/.cas and .dat, images/.jpeg, bioreactor-CAD/.stl or .scdoc

Funding

  • 4TU.ResearchData FAIR Data Fund
  • e-infra Snellius CFD-derived data for surrogate models of bioreactors (grant code NWO/EINF - 11590) SURF Cooperative

Organizations

TU Delft, Faculty of Applied Sciences, Department of Biotechnology

DATA

Files (5)