Data underlying the publication: Absorption of iron from edible house crickets: a randomized crossover stable-isotope study in humans

DOI:10.4121/19111334.v1
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DOI: 10.4121/19111334

Datacite citation style

Mwangi, Martin N.; Dennis Oonincx; Hummel, Marijke; Utami, Dessy A.; Gunawan, Lidyawati et. al. (2025): Data underlying the publication: Absorption of iron from edible house crickets: a randomized crossover stable-isotope study in humans. Version 1. 4TU.ResearchData. dataset. https://doi.org/10.4121/19111334.v1
Other citation styles (APA, Harvard, MLA, Vancouver, Chicago, IEEE) available at Datacite

Dataset

In this exploratory study, we assessed fractional iron absorption from house crickets (Acheta domesticus) consumed with refined (low-phytate, noninhibiting) or nonrefined (high-phytate, inhibiting) meals. Intrinsically [57Fe]-labeled and control crickets were reared. Six iron-balanced experimental meals were randomly

administered crossover to 20 iron-depleted females (serum ferritin <25 μg/L; 18–30 y old), in 2 time-blocks of 3 consecutive days, 2 wk apart. Three meals consisted of refined maize flour porridge with either [57Fe]-labeled crickets, [58Fe]SO4 (reference meal), or unlabeled crickets plus [54Fe]SO4. The other 3 meals consisted of

nonrefined maize flour porridge with the same respective additions. Blood samples were drawn to assess the 14-d isotope enrichment in erythrocytes, and meal-specific fractional iron absorption was calculated. In vitro digestion was used to explore possible explanations for unexpected findings. Mean fractional iron absorption from 57Fe-labeled house crickets with refined maize porridge (3.06%) and from refined maize porridge with unlabeled crickets (4.92%) was lower than from the referencemeal (14.2%), with respective mean differences of−11.1% (95% CI: −12.6%, −9.68%) and −9.29% (95% CI: −10.8%, −7.77%). Iron absorption from all meals based on unrefined maize porridge was low (<3%), and did not differ for the 2 meals with crickets compared with the reference meal. In vitro digestion showed that chitin, chitosan, and calcium limited iron bioaccessibility to a large extent. Iron absorption from house crickets and fortified maize porridge with crickets is low, which may be explained by the presence of chitin and other inhibitors in the cricket biomass. This trial was registered at https://www.trialregister.nl as NL6821.

History

  • 2025-05-23 first online, published, posted

Publisher

4TU.ResearchData

Format

Excel

Funding

  • Wellcome Trust

Organizations

Division of Human Nutrition and Health, Wageningen University & Research
Laboratory of Entomology, Wageningen University & Research, the Netherlands
Human Nutrition Laboratory, ETH Zürich, Switzerland

DATA

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