Data underlying the publication: Microscale 3D-Printed Biocompatible, Soft Silicone Nerve Cuff for the Mouse Vagus Nerve

DOI:10.4121/9aae342d-3a21-4034-a034-f3b4d940a484.v1
The DOI displayed above is for this specific version of this dataset, which is currently the latest. Newer versions may be published in the future. For a link that will always point to the latest version, please use
DOI: 10.4121/9aae342d-3a21-4034-a034-f3b4d940a484

Datacite citation style

Currie, Tyler; McLeod, Robert; Weir, Richard; Fontaine, Arjun (2025): Data underlying the publication: Microscale 3D-Printed Biocompatible, Soft Silicone Nerve Cuff for the Mouse Vagus Nerve. Version 1. 4TU.ResearchData. dataset. https://doi.org/10.4121/9aae342d-3a21-4034-a034-f3b4d940a484.v1
Other citation styles (APA, Harvard, MLA, Vancouver, Chicago, IEEE) available at Datacite

Dataset

This dataset includes measurements for the Jacob’s Working Curve of BioRes-Silicone and electrocardiogram (ECG) recordings from in-vivo heart rate modulation experiments. For the Jacob’s Working Curve, three types of data were collected: (1) power readings obtained at the beginning of the experiment using a power meter; (2) exposure time which was set via MATLAB code (Mathworks); and (3) thickness measurement taken manually with a digital caliper (Neiko) capable of measuring to two decimal places. The Jacob’s Working Curve enables the use of BioRes-Silicone on other digital light processing (DLP) 3D-printing systems. The ECG data were collected from an adult ChAT-Cre (homozygous) × ChR2 (homozygous) mouse to observe heart rate reduction in response to blue light stimulation of channelrhodopsin-2 (ChR2) in the vagus nerve. Recordings were acquired using a PowerLab 2/26 bioamplifier (ADInstruments) and processed in LabChart software (ADInstruments). The final .txt file was exported directly from LabChart. These data confirm the nerve cuff successfully stimulates the vagus nerve.

History

  • 2025-04-14 first online, published, posted

Publisher

4TU.ResearchData

Format

A .xlsx file and a .txt file

Funding

  • A 3D-Printed Nerve Cuff for 1-Photon Optogenetic Vagal Stimulation (grant code NINDS R21 NS124313-01) National Institute of Neurological Disorders and Stroke
  • Optimization of a Minimally Invasive Bidirectional Optogenetic Peripheral Nerve Interface with Single Axon Read-in & Read-out Specificity (grant code NIH NINDS R01NS118188) National Institute of Health
  • Investigation of an Optogenetic Vagus Nerve Stimulation Device in an Animal Model of Post-traumatic Stress Disorder (grant code I21 RX003894-01) Department of Veterans Affairs, Rehabilitation Research and Development Service

Organizations

University of Colorado Denver | Anschutz, Department of Bioengineering, College of Engineering, Design and Computing

DATA

Files (3)