The doi above is for this specific version of this dataset, which is currently the latest. Newer versions may be published in the future. For a link that will always point to the latest version, please use
doi: 10.4121/983ad43d-4fad-4808-ade9-d30a03d836bb

Fu, Shengling; Zhou, Yu-cong; Fang, Hu; Ouyang, Haoliang; Li, Shihua et. al. (2024): Data underlying the publication: Neuroprotective Effects of Everolimus via Regulation of Autophagy-Related Proteins in a Cerebral Ischemia-Reperfusion Rat Model. Version 1. 4TU.ResearchData. dataset. https://doi.org/10.4121/983ad43d-4fad-4808-ade9-d30a03d836bb.v1

Dataset

• Neurosciences
• Pharmacology and Pharmaceutical Sciences
• Medical and Health Sciences

Akt, Beclin-1, Cellular autophagy, everolimus, ischemic stroke, LC3-I, LC3-II, Middle cerebral artery occlusion (MCAO), mTOR, pAkt, PI3K, pPI3K

CC BY-NC-SA 4.0

RefWorks, BibTeX, Reference Manager, Endnote, DataCite, NLM, DC, CFF

by Shengling Fu , Yu-cong Zhou , Hu Fang , Haoliang Ouyang , Shihua Li , Jinping Xiao , Hao Liu

The data was collected from MCAO rats to evaluate the neuroprotection of everolimus. In excel file, the Longa’s neurological scale was applied to evaluate neurobehavioral deficit in ischemia/reperfusion-induced rats, and the ischemic infarct area of each section was calculated as infarct size. Besides, immunochemical staining of MCAO rats for mTOR and Beclin-1 expression was uploaded to observe the influence of everolimus on mTOR and Beclin-1. Besides, the data also included WB images of pPI3K, PI3K, pAkt, Akt, LC3-I, LC3-II. This study explored the effect of everolimus on the expression of PI3K, LC3, and Akt proteins and further clarified the regulatory mechanism of nerve cell autophagy against neural lesions.

• 2024-08-01 first online, published, posted

4TU.ResearchData

*.xlsx, *.tif, *.png

State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China