The doi above is for this specific version of this dataset, which is currently the latest. Newer versions may be published in the future. For a link that will always point to the latest version, please use
doi: 10.4121/882b82f6-0a21-445a-a0ae-65324c73cb05

Liu, Juncheng; Brevé, Tobias G.; Xu, Bing; Hagedoorn, Peter-Leon; Denkova, Antonia et. al. (2024): Data underlying the publication: Organochlorides Mediate Oxidation Reactions Induced by Low Dose Ionizing RadiationOrganochlorides Mediate Oxidation Reactions Induced by Low Dose Ionizing Radiation. Version 1. 4TU.ResearchData. dataset. https://doi.org/10.4121/882b82f6-0a21-445a-a0ae-65324c73cb05.v1

Dataset

• Organic Chemistry
• Macromolecular and Materials Chemistry
• Chemical Sciences

drug delivery, ionizing radiation, micelles, radiation chemistry, reaction mechanisms, reactive oxygen species

2020-2023

CC0

RefWorks, BibTeX, Reference Manager, Endnote, DataCite, NLM, DC, CFF

by Juncheng Liu , Tobias G. Brevé , Bing Xu , Peter-Leon Hagedoorn , Antonia Denkova , Rienk Eelkema

The controlled release of drugs using local ionizing radiation presents a promising approach for targeted cancer treatment, particularly when applied in concurrent radio-chemotherapy. In these approaches, radiation-generated reactive species often play an important role. However, the reactive species that can be used to trigger release have low yield and lack selectivity. Here, we demonstrate the generation of highly oxidative species when aqueous solutions containing low concentrations of organochlorides (such as chloroform) are irradiated with ionizing radiation at therapeutically relevant doses. These reactive species were identified as peroxyl radicals, which formed in a reaction cascade between organochlorides and aqueous electrons. We employed stilbene-based probes to investigate the oxidation process, showing double bond oxidation and cleavage. To translate this reactivity into a radiation-sensitive material, we have synthesized a micelle forming amphiphilic block copolymer that has stilbene as the linker between two blocks. Upon exposure to ionizing radiation, the oxidation of stilbene led to the cleavage of the polymer, which induces the dissociation of the block-copolymer micelles and the release of loaded drugs.

• 2024-10-17 first online, published, posted

4TU.ResearchData

UV spectrum raw data/.CSV; Origin plot data/.opju; graphs/.tif; NMR data/.mnova; TEM images/.tif; EPR raw data/.DSC

Organochlorides Mediate Oxidation Reactions Induced by Low Dose Ionizing Radiation

• China Scholarship Council (CSC)

TU Delft, Faculty of Applied Sciences, Department of Radiation Science & Technology