Zhong, Yi (2024): Data underlying the publication: Activation of PAR-2/p-ERK/GPX4 axis is involved in MCT-induced PAH and hypoxia-induced PASMCs proliferation. Version 1. 4TU.ResearchData. dataset. https://doi.org/10.4121/534cc141-f45b-4cdb-b61b-7b34d80f035a.v1

Dataset

x choose version: version 2 - 2024-10-10 (latest)

• Cardiorespiratory Medicine and Haematology
• Medical and Health Sciences

ferroptosis, glutathione peroxidase 4, monocrotaline, phosphorylated extracellular signal-regulated kinases, protease-activated receptor-2, pulmonary arterial smooth muscle cells, pulmonary artery hypertension

CC0

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by Yi Zhong

Title of the dataset: Data underlying the publication: Activation of PAR-2/p-ERK/GPX4 axis is involved in MCT-induced PAH and hypoxia-induced PASMCs proliferation. The dataset contains 5 pictures and 37 files in pzfx format. The 37 files in pzfx format contain experimental data related to the content of the pictures. For example, "Fig1A. media to vessel diameter ratio.pzfx" contains the data of "media to vessel diameter ratio" shown in A in Fig 1. There are a total of 5 pictures: Fig 1: Formation of MCT-induced rats PAH. Fig 2: An increase in the expression of protein PAR-2, p-ERK and GPX4 was observed in the lung tissue of rats with MCT-induced PAH. Fig 3: Hypoxia induces a time-dependent proliferation of PASMCs within 6 hours, accompanied by increased expression of PAR-2, p-ERK and GPX4. Fig 4: FSLL, a PAR-2 inhibitor, inhibited hypoxia-induced proliferation and regulated the expression of PAR-2, p-ERK and GPX4 in rat PASMCs. Fig5: Inhibition of MEK1/2/p-ERK with U0126 suppressed hypoxia-induced proliferation in rat PASMCs and regulated the expression of PAR -2 ,p - ERK,and GPX4. The research objectives are MCT-induced PAH rats and PASMCs. The type of research is an experimental prospective study. Methodology for data collection and type: All data collected were from animal and cells experiments, with all data types being numerical.

• 2024-09-12 first online, published, posted

4TU.ResearchData

Graphpad Prism/pzfx；image/jpeg；

• Activation of PAR-2/p-ERK/GPX4 axis is involved in MCT-induced PAH and hypoxia-induced PASMCs proliferation Soochow Health Committee of Science and Technology Projects

The Fourth Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China；
The Second People's Hospital of Huai’an, Huai’an, Jiangsu, China.