The doi above is for this specific version of this dataset, which is currently the latest. Newer versions may be published in the future. For a link that will always point to the latest version, please use
doi: 10.4121/18865163

Xiao-Qin He (2022): Data underlying the research of: “Prevention of ulcerative colitis in mice by sweet tea (Lithocarpus litseifolius) via the regulation of gut microbiota and butyric acid-mediated anti-inflammatory signaling". Version 1. 4TU.ResearchData. dataset. https://doi.org/10.4121/18865163.v1

Dataset

• Immunology

Gut microbiota, HDAC3/NF-κB signaling pathway, Inflammatory bowel disease, sweet tea (Lithocarpus litseifolius)

CC0

RefWorks, BibTeX, Reference Manager, Endnote, DataCite, NLM, DC, CFF

by Xiao-Qin He

Sweet tea (Lithocarpus litseifolius [Hance] Chun) is a new resource for food raw materials with plenty of health functions. However, whether sweet tea can prevent ulcerative colitis (UC) remains unclear. The aim of this study was to investigate the preventive effect and potential mechanism of sweet tea extract (STE) on UC in mice. 3% Dextran sulfate sodium (DSS) induced UC mice were treated with either STE (100 and 400 mg/kg·bw), salicylazosulfapyridine (SASP) or distilled water for 2 weeks. The severity of UC were mainly evaluated by disease activity index (DAI) score, colon inflammatory markers and colon histopathological examination. The proteins expression were explored by immunohistochemistry and western blot. Gut microbiota composition and short-chain fatty acid content were analyzed by 16S rRNA sequencing and GC-MS metabolic assay, respectively.

• 2022-01-26 first online, published, posted

4TU.ResearchData

xlsx, jpg

• the Local Financial Funds of National Agricultural Science and Technology Center, Chengdu (No. NASC2020KR02)

Research Center for Plants and Human Health, Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu.