BioBrAIn: Stavanger 22m3 bioreactor - CFD-derived data

DOI:10.4121/34c5d95d-2e34-4087-b970-5f14b7463d44.v1
The DOI displayed above is for this specific version of this dataset, which is currently the latest. Newer versions may be published in the future. For a link that will always point to the latest version, please use
DOI: 10.4121/34c5d95d-2e34-4087-b970-5f14b7463d44

Datacite citation style

Maldonado de León, Héctor; Naderibeni, Mahdi; Haringa, Cees (2025): BioBrAIn: Stavanger 22m3 bioreactor - CFD-derived data. Version 1. 4TU.ResearchData. dataset. https://doi.org/10.4121/34c5d95d-2e34-4087-b970-5f14b7463d44.v1
Other citation styles (APA, Harvard, MLA, Vancouver, Chicago, IEEE) available at Datacite

Dataset

Access to publicly available detailed information on industrial-scale fermentors is limited; most studies date back to the 1980s and 1990s, before the widespread availability of affordable computing power. Among these, the EU-Project "Bioprocess Scale-up Strategy" analyzed a 30 cubic meter reactor design for a fed-batch process with a maximum working volume of 22 cubic meters equipped with Rushton Turbine (RT) impellers. Here, we focus on the configuration using solely RT-impellers. The studies by Bylund et al. and Vrábel et. al provide detailed descriptions of the reactor geometry, pulse-response experiments for mixing time determination, and the process conditions. Notably, the available data spans a wide range of operating conditions—both aerated and non-aerated—resulting in distinct impeller flow regimes (i.e., flooding, loading, and transitional states).


Based on these studies, CFD simulations were conducted across the operating conditions summarized in the `dp_op_conditions.csv` file and also the README.md file. Further information on the dimensions of the stirred tank, mesh, and model parameterization can be found in the README.md file and config.json files per design point, respectively.


The accompanying documentation for the entire data collection (database) and a visualization manual can be found in DOI: 10.4121/27fd363b-1310-4a69-9635-aa50d9bb7823


This dataset is part of the BioBrAIn collection - A CFD database of bioreactors (DOI: 10.4121/b99ff905-7bfa-4d13-a429-e2daad2d7579).

This project was supported by the 4th edition of the FAIR Data Fund from 4TU.ResearchData.

History

  • 2025-11-03 first online, published, posted

Publisher

4TU.ResearchData

Format

Fluent case & data /.cas & .dat; cfd-derived-data/.csv; EnSight Case Gold files/.encas; image/.png, mesh/.msh

Funding

  • 4TU.ResearchData FAIR Data Fund
  • e-infra Snellius CFD-derived data for surrogate models of bioreactors (grant code NWO/EINF - 11590) SURF Cooperative

Organizations

TU Delft, Faculty of Applied Sciences, Department of Biotechnology

DATA

Files (4)